The Western Hemisphere before 1492. It was, in the current view, a thriving, stunningly diverse place, a tumult of languages, trade, and culture, a region where tens of millions of people loved and hated and worshipped as people do everywhere. Much of this world vanished after Columbus, swept away by disease and subjugation. So thorough was the erasure that within a few generations neither conqueror nor conquered knew that this world had existed. Now, though, it is returning to view. It seems incumbent on us to take a look...

Mesoamerica would deserve its place in the human pantheon if its inhabitants had only created maize, in terms of harvest weight the world’s most important crop. But the inhabitants of Mexico and northern Central America also developed tomatoes, now basic to Italian cuisine; peppers, essential to Thai and Indian food; all the world’s squashes (except for a few domesticated in the United States); and many of the beans on dinner plates around the world. One writer has estimated that Indians developed three-fifths of the crops now in cultivation, most of them in Mesoamerica. Having secured their food supply, Mesoamerican societies turned to intellectual pursuits. In a millennium or less, a comparatively short time, they invented their own writing, astronomy, and mathematics, including the zero....

In 1491 the Inka ruled the greatest empire on earth. Bigger than Ming Dynasty China, bigger than Ivan the Great’s expanding Russia, bigger than Songhay in the Sahel or powerful Great Zimbabwe in the West Africa tablelands, bigger than the cresting Ottoman Empire, bigger than the Triple Alliance (as the Aztec empire is more precisely known), bigger by far than any European state, the Inka dominion extended over a staggering thirty-two degrees of latitude—as if a single power held sway from St. Petersburg to Cairo....

When microbes arrived in the Western Hemisphere...they must have swept from the coastlines first visited by Europeans to inland areas populated by Indians who had never seen a white person. Colonial writers knew that disease tilled the virgin soil of the Americas countless times in the sixteenth century. But what they did not, could not, know is that the epidemics shot out like ghastly arrows from the limited areas they saw to every corner of the hemisphere, wreaking destruction in places that never appeared in the European historical record. The first whites to explore many parts of the Americas therefore would have encountered places that were already depopulated...

—- Charles C. Mann’s 1491: New Revelations of the Americas Before Columbus