Can picking your nose kill you? Sure picking your nose can kill you, but it's not easy. Truth is, a picking obsession is much more likely to cost you your friends than your life. The deadly threat of nose picking comes from the fact that the vein that takes blood away from your nose connects with ones that also drain your brain. So if you pick too vigorously, you could break skin and expose your system to the germs on your finger. Those germs could then cause an infection, which might spread through the blood vessels and clog up the vein that drains your brain. As a result, your brain could fill up like a water balloon and you could die.